{"id":787,"date":"2023-09-03T14:07:07","date_gmt":"2023-09-03T17:07:07","guid":{"rendered":"https:\/\/peledigital.com\/blog\/?p=787"},"modified":"2023-09-03T14:07:07","modified_gmt":"2023-09-03T17:07:07","slug":"dupilumabe-upadacitinibe-e-da-cefalica","status":"publish","type":"post","link":"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/","title":{"rendered":"Dupilumabe Upadacitinibe e DA cef\u00e1lica"},"content":{"rendered":"\n

Qual \u00e9 a rela\u00e7\u00e3o entre Dupilumabe Upadacitinibe e DA cef\u00e1lica?<\/p>\n\n\n\n

Primeiramente vamos lembrar que as les\u00f5es de cabe\u00e7a e pesco\u00e7o s\u00e3o naturalmente mais resistentes ao tratamento com dupilumabe? <\/p>\n\n\n\n

N\u00e3o se sabe o motivo e algumas teorias surgem a respeito do assunto. <\/p>\n\n\n\n

Lebro que este \u00e9 um dos artigos de nossa s\u00e9rie de artigos que fala como os\u00a0Inibidores de\u00a0JAK v\u00e3o mudar a dermatologia<\/a><\/p>\n\n\n\n

Antes de falarmos de teoria, vamos trazer o artigo Effectiveness and safety of upadacitinib in patients with face and neck atopic<\/a> dermatitis unresponsive to dupilumab<\/a><\/p>\n\n\n\n

Os autores, com o intuito de avaliar o impacto do upadacitinibe nas les\u00f5es de cabe\u00e7a e pesco\u00e7o que s\u00e3o resistentes ao uso do Dupilumabe, avaliam retrospectivamente uma s\u00e9rie de casos. <\/p>\n\n\n\n

O upadacitinibe \u00e9 um inibidor de JAK com seletividade preferencia para as JAK 1 e 2 em rela\u00e7\u00e3o a JAK3 e TYK 2. com aprova\u00e7\u00e3o de uso para portadores de Dermatite At\u00f3pica acima de 12 anos n\u00e3o responsivo a outras terapias.<\/p>\n\n\n\n

Com foco nas les\u00f5es cef\u00e1lica, o crit\u00e9rio para inclus\u00e3o foi a presen\u00e7a de les\u00e3o na regi\u00e3o de cabe\u00e7a e pesco\u00e7o mesmo com uso de Dupilumabe.<\/p>\n\n\n\n

Os autores demonstram melhora dos casos com impactos nos par\u00e2metros cl\u00ednicos como EASI, DLQI e NRSp, assim como de alguns par\u00e2metros laboratoriais, estes sem signific\u00e2ncia estat\u00edstica.<\/p>\n\n\n\n

Ao avaliar este artigo tenho as seguintes perguntas:<\/p>\n\n\n\n

    \n
  1. Em vez de substituir o dupilumabe, poder\u00edamos usar o upadacitinibe para tratar as les\u00f5es residuais?<\/li>\n\n\n\n
  2. Poder\u00edamos suspender o upadacitinibe ap\u00f3s melhoras das les\u00f5es e controlar a doen\u00e7a com o dupilumabe?<\/li>\n\n\n\n
  3. Seriam as les\u00f5es residuais influenciadas por mecanismos independentes da IL-4 e IL-13?<\/li>\n<\/ol>\n\n\n\n

    Estamos numa nova fase do tratamento da dermatite at\u00f3pica, onde oferecemos tratamentos mais eficazes e mais seguros.<\/p>\n\n\n\n

    Como m\u00e9dicos precisamos continuar, talvez intensificar, as nossas atualiza\u00e7\u00f5es, que \u00e9 o objetivo deste post<\/p>\n","protected":false},"excerpt":{"rendered":"

    Artigo que fala do uso de upadacitinibe em pacientes com les\u00f5es de cabe\u00e7a e pesco\u00e7o que n\u00e3o respondem ao uso de dupilumabe<\/p>\n","protected":false},"author":1,"featured_media":788,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-787","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sem-categoria"],"acf":[],"yoast_head":"\nDupilumabe Upadacitinibe e DA cef\u00e1lica - Pele Digital<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dupilumabe Upadacitinibe e DA cef\u00e1lica - Pele Digital\" \/>\n<meta property=\"og:description\" content=\"Artigo que fala do uso de upadacitinibe em pacientes com les\u00f5es de cabe\u00e7a e pesco\u00e7o que n\u00e3o respondem ao uso de dupilumabe\" \/>\n<meta property=\"og:url\" content=\"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/\" \/>\n<meta property=\"og:site_name\" content=\"Pele Digital\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-03T17:07:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/peledigital.com\/blog\/wp-content\/uploads\/2023\/09\/Untitled-7.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabio Francesconi\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabio Francesconi\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/\",\"url\":\"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/\",\"name\":\"Dupilumabe Upadacitinibe e DA cef\u00e1lica - Pele Digital\",\"isPartOf\":{\"@id\":\"https:\/\/peledigital.com\/blog\/#website\"},\"datePublished\":\"2023-09-03T17:07:07+00:00\",\"dateModified\":\"2023-09-03T17:07:07+00:00\",\"author\":{\"@id\":\"https:\/\/peledigital.com\/blog\/#\/schema\/person\/e8de861b1668d79f5a37ffe805b71ba5\"},\"breadcrumb\":{\"@id\":\"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\/\/peledigital.com\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Dupilumabe Upadacitinibe e DA cef\u00e1lica\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/peledigital.com\/blog\/#website\",\"url\":\"https:\/\/peledigital.com\/blog\/\",\"name\":\"Pele Digital\",\"description\":\"Vestindo a pele do futuro\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/peledigital.com\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/peledigital.com\/blog\/#\/schema\/person\/e8de861b1668d79f5a37ffe805b71ba5\",\"name\":\"Fabio Francesconi\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\/\/peledigital.com\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/4226959ef05a7ab22bb42e1838c11f56385fd6b30c04a44058dd185b369340ed?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/4226959ef05a7ab22bb42e1838c11f56385fd6b30c04a44058dd185b369340ed?s=96&d=mm&r=g\",\"caption\":\"Fabio Francesconi\"},\"sameAs\":[\"https:\/\/blog.peledigital.com\"],\"url\":\"https:\/\/peledigital.com\/blog\/author\/fabio\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dupilumabe Upadacitinibe e DA cef\u00e1lica - Pele Digital","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/","og_locale":"pt_BR","og_type":"article","og_title":"Dupilumabe Upadacitinibe e DA cef\u00e1lica - Pele Digital","og_description":"Artigo que fala do uso de upadacitinibe em pacientes com les\u00f5es de cabe\u00e7a e pesco\u00e7o que n\u00e3o respondem ao uso de dupilumabe","og_url":"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/","og_site_name":"Pele Digital","article_published_time":"2023-09-03T17:07:07+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/peledigital.com\/blog\/wp-content\/uploads\/2023\/09\/Untitled-7.png","type":"image\/png"}],"author":"Fabio Francesconi","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"Fabio Francesconi","Est. tempo de leitura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/","url":"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/","name":"Dupilumabe Upadacitinibe e DA cef\u00e1lica - Pele Digital","isPartOf":{"@id":"https:\/\/peledigital.com\/blog\/#website"},"datePublished":"2023-09-03T17:07:07+00:00","dateModified":"2023-09-03T17:07:07+00:00","author":{"@id":"https:\/\/peledigital.com\/blog\/#\/schema\/person\/e8de861b1668d79f5a37ffe805b71ba5"},"breadcrumb":{"@id":"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/peledigital.com\/blog\/dupilumabe-upadacitinibe-e-da-cefalica\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/peledigital.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Dupilumabe Upadacitinibe e DA cef\u00e1lica"}]},{"@type":"WebSite","@id":"https:\/\/peledigital.com\/blog\/#website","url":"https:\/\/peledigital.com\/blog\/","name":"Pele Digital","description":"Vestindo a pele do futuro","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/peledigital.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"pt-BR"},{"@type":"Person","@id":"https:\/\/peledigital.com\/blog\/#\/schema\/person\/e8de861b1668d79f5a37ffe805b71ba5","name":"Fabio Francesconi","image":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/peledigital.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/4226959ef05a7ab22bb42e1838c11f56385fd6b30c04a44058dd185b369340ed?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4226959ef05a7ab22bb42e1838c11f56385fd6b30c04a44058dd185b369340ed?s=96&d=mm&r=g","caption":"Fabio Francesconi"},"sameAs":["https:\/\/blog.peledigital.com"],"url":"https:\/\/peledigital.com\/blog\/author\/fabio\/"}]}},"_links":{"self":[{"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/posts\/787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/comments?post=787"}],"version-history":[{"count":1,"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/posts\/787\/revisions"}],"predecessor-version":[{"id":789,"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/posts\/787\/revisions\/789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/media\/788"}],"wp:attachment":[{"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/media?parent=787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/categories?post=787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peledigital.com\/blog\/wp-json\/wp\/v2\/tags?post=787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}