{"id":773,"date":"2023-09-02T12:05:36","date_gmt":"2023-09-02T15:05:36","guid":{"rendered":"https:\/\/peledigital.com\/blog\/?p=773"},"modified":"2023-09-02T12:45:38","modified_gmt":"2023-09-02T15:45:38","slug":"retratamento-com-upadacitinibe","status":"publish","type":"post","link":"https:\/\/peledigital.com\/blog\/retratamento-com-upadacitinibe\/","title":{"rendered":"Retratamento com Upadacitinibe"},"content":{"rendered":"\n

Hoje vamos falar de retratamento com Upadacitinibe, visto que falha secund\u00e1ria \u00e9 um dos grandes medos quando suspendemos as drogas imunomoduladoras.<\/p>\n\n\n\n

Este post faz parte de nossa s\u00e9rie de artigos que fala como os Inibidores de JAK v\u00e3o mudar a dermatologia<\/a><\/p>\n\n\n\n

Uma das grandes d\u00favidas que temos no tratamento das doen\u00e7as imunomediadas \u00e9:<\/p>\n\n\n\n

Quando podemos parar o tratamento?<\/h4>\n\n\n\n

Essa \u00e9 a proposta do artigo – Retreatment with upadacitinib in atopic dermatitis: experience in clinical practice<\/a><\/p>\n\n\n\n

O objetivo dos tratamentos das doen\u00e7as imunomediadas \u00e9 o controle dos sintomas e limitar a progress\u00e3o, pois sabemos a cura ainda n\u00e3o conseguimos proporcionar. <\/p>\n\n\n\n

Ser\u00e1 que se suspendermos o upadacitinibe, manteremos a efic\u00e1cia da medica\u00e7\u00e3o no caso de reintrodu\u00e7\u00e3o da mesma?<\/p>\n\n\n\n

Esta \u00e9 uma das vantagens te\u00f3ricas do inibidores de JAK, quando comparados com os imunobiol\u00f3gicos. <\/p>\n\n\n\n

N\u00e3o temos a produ\u00e7\u00e3o de autoanticorpos contra os inibidores de JAK, logo a perda de resposta seria improv\u00e1vel. <\/p>\n\n\n\n

Com o intu\u00edto de sair da teoria, o artigo avalia 03 casos de reintrodu\u00e7\u00e3o do upadacitinibe. Em todos os casos houve resposta com a medica\u00e7\u00e3o<\/p>\n\n\n\n

Em dois desses casos o paciente estava em uso de imunobiol\u00f3gico (dupilumabe em um e o traliquinumabe no outro) que n\u00e3o foram capazes de controlar a doen\u00e7a, mas o upa controlou.<\/p>\n\n\n\n

Similarmente um estudo fase 02 estimou que em 81% dos casos de interrup\u00e7\u00e3o do upadacitinibe voltam a precisar da medica\u00e7\u00e3o e que na reintrodu\u00e7\u00e3o a efic\u00e1cia se mant\u00e9m.<\/p>\n\n\n\n

Este estudo avalia 03 casos graves fato que abre uma janela de oportunidade terap\u00eautica.<\/p>\n\n\n\n

Eu vejo o upadacitinibe como uma medica\u00e7\u00e3o interessante para o controle de surtos de agudiza\u00e7\u00e3o dos sintomas. Em contrapartida aos imunobiol\u00f3gicos os inibidores de JAK podem ser armas no controle de crises e n\u00e3o apenas utilizadas para o controle de longo prazo.<\/p>\n\n\n\n

E ao ler este artigo eu pergunto: voc\u00ea faria retratamento com Upadacitinibe?<\/p>\n\n\n\n

Eu faria<\/p>\n\n\n\n

N\u00e3o deixem de estudar os inibidores de JAK, pois cada vez mais iremos usa-los em nossa rotina e no tratamento e retratamento de nossos pacientes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Este artigo ajuda a responder uma das d\u00favidas relacionadas ao uso dos inibidores de JAK, neste caso do upadacitinibe. Ser\u00e1 que podemos suspender a medica\u00e7\u00e3o e reutilizar em caso de retorno dos sintomas?<\/p>\n","protected":false},"author":1,"featured_media":774,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[37,28,24,29,35],"class_list":["post-773","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-imunologia","tag-dermatite-atopica","tag-imunoxpert","tag-inibidores-de-jak","tag-pele-digital","tag-upadacitinibe"],"acf":[],"yoast_head":"\nRetratamento com Upadacitinibe - Pele Digital<\/title>\n<meta name=\"description\" content=\"Retratamento com Upadacitinibe em portadores de dermatite at\u00f3pica. 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