{"id":758,"date":"2023-09-01T15:40:04","date_gmt":"2023-09-01T18:40:04","guid":{"rendered":"https:\/\/peledigital.com\/blog\/?p=758"},"modified":"2023-09-04T15:16:37","modified_gmt":"2023-09-04T18:16:37","slug":"jak-no-prurigo-nodular","status":"publish","type":"post","link":"https:\/\/peledigital.com\/blog\/jak-no-prurigo-nodular\/","title":{"rendered":"JAK no Prurigo Nodular"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Neste artigo vamos falar dos inibidores de JAK no prurigo nodular, como parte da nossa s\u00e9rie de artigos listada no post Inibidores de&nbsp;<a href=\"https:\/\/peledigital.com\/inibidores-de-jak-vao-mudar-a-dermatologia\/\">JAK v\u00e3o mudar a dermatologia<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">O <a href=\"https:\/\/dermnetnz.org\/topics\/nodular-prurigo\">prurigo nodular<\/a> \u00e9 de dif\u00edcil controle, pois \u00e9 uma doen\u00e7a cr\u00f4nica, recidivante refrat\u00e1ria aos medicamentos usuais.<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Mais recentemente, esta doen\u00e7a foi enquadrada dentro do grupo das doen\u00e7as com perfil Th2 e tamb\u00e9m como um subtipo da dermatite at\u00f3pica do idoso, como um fen\u00f3tipo a parte.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\"><strong>Dessa forma, o prurigo nodular \u00e9<\/strong><\/mark><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\"> uma<\/mark><\/strong> <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\"><strong>doen\u00e7a de perfil Th2<\/strong><\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A publica\u00e7\u00e3o <a href=\"https:\/\/www.jaadinternational.org\/action\/showPdf?pii=S2666-3287%2823%2900094-9\">Comparison between dupilumab and oral Janus kinase inhibitors in the treatment of prurigo nodularis with or without atopic dermatitis in a tertiary care center in Singapore<\/a>, compara duas medica\u00e7\u00f5es utilizadas nas doen\u00e7as perfil Th2:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dupilumabe<\/li>\n\n\n\n<li>Inibidores de JAK\n<ul class=\"wp-block-list\">\n<li>Baricitinibe<\/li>\n\n\n\n<li>Upadacitinibe<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Apesar dos autores apresentarem o artigo como de coorte, na minha interpreta\u00e7\u00e3o trata-se de uma s\u00e9rie de casos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">De forma retrospectiva os autores compararam a resposta dos pacientes portadores de prurigo nodular, com ou sem dermatite at\u00f3pica, tratados com dupilumabe (36 pacientes) com&nbsp;os tratados com inibidor de JAK (13 pacientes com baricitinibe ou upadacitinibe) <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O objetivo do trabalho \u00e9 avaliar o impacto de cada medica\u00e7\u00e3o nos diferentes par\u00e2metros do prurigo e dessa forma compara-los. Vale ver a tabela do artigo<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alguns aspectos chamaram a aten\u00e7\u00e3o:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>O tempo da primeira resposta foi de 3.65 semanas para o inibidor de JAK em contraste com  10.7 semanas para o dupilumabe;<\/li>\n\n\n\n<li>Ao longo de 10 semanas a redu\u00e7\u00e3o do prurido foi levemente superior para os tratados com dupilumabe, por\u00e9m essa diferen\u00e7a n\u00e3o teve signific\u00e2ncia estast\u00edstica<\/li>\n\n\n\n<li>Todos os pacientes inclu\u00eddos tinham hist\u00f3rico de tratamento com alguma outra medica\u00e7\u00e3o<\/li>\n\n\n\n<li>O n\u00famero de infec\u00e7\u00f5es cut\u00e2neas foi maior no grupo que utilizou os inibidores de JAK<\/li>\n\n\n\n<li>Melhor respota das les\u00f5es de cabe\u00e7a e pesco\u00e7o com inibidores de JAK<\/li>\n\n\n\n<li>Tratamento t\u00f3pico ou intralesional esteve associado em todos os pacientes<\/li>\n<\/ol>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>O artigo que mostra uma a\u00e7\u00e3o mais r\u00e1pida dos inibidores de JAK, por\u00e9m com um melhor controle da doen\u00e7a em longo prazo com o dupilumabe. <\/p><\/blockquote><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Mesmo sem termos todas as respostas, inegavelmente estamos diante de duas excelente op\u00e7\u00f5es terap\u00eauticas para uma doen\u00e7a que at\u00e9 pouco tempo era de dif\u00edcil controle. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Quando usar inibidor de jak (upadacitinibe ou baricitinibe) ou dupilumabe no tratamento do prurigo nodular? <\/p>\n","protected":false},"author":1,"featured_media":760,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[30,32,34,36,24,31,33,35],"class_list":["post-758","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-imunologia","tag-baricitinibe","tag-dermatite-atopica-do-idoso","tag-dupilumabe","tag-inibidor-de-jak","tag-inibidores-de-jak","tag-perfil-th2","tag-prurigo-nodular","tag-upadacitinibe"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>JAK no Prurigo Nodular - Pele Digital<\/title>\n<meta name=\"description\" content=\"JAK no Prurigo Nodular. 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