{"id":744,"date":"2023-09-01T14:19:36","date_gmt":"2023-09-01T17:19:36","guid":{"rendered":"https:\/\/peledigital.com\/blog\/?p=744"},"modified":"2023-09-01T16:05:07","modified_gmt":"2023-09-01T19:05:07","slug":"tofacitinibe-e-granuloma-cutaneo","status":"publish","type":"post","link":"https:\/\/peledigital.com\/blog\/tofacitinibe-e-granuloma-cutaneo\/","title":{"rendered":"Tofacitinibe e granuloma cut\u00e2neo"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Hoje vamos falar do uso de tofacitinibe e granuloma cut\u00e2neo, na nossa s\u00e9rie de artigos listada no post <a href=\"https:\/\/peledigital.com\/blog\/inibidores-de-jak-vao-mudar-a-dermatologia\/\">Inibidores de\u00a0JAK v\u00e3o mudar a dermatologia<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trago a publica\u00e7\u00e3o intitulada&nbsp;<a href=\"https:\/\/www.tandfonline.com\/doi\/epdf\/10.1080\/09546634.2023.2244616?needAccess=true&amp;role=button\">Two cases of lupus miliaris disseminatus faciei successfully treated with oral tofacitinib<\/a>.&nbsp;<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Neste artigo os autores relatam dois casos de lupus miliaris disseminatus faciei tratados com tofacitinibe<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">A doen\u00e7a est\u00e1 classicamente relacionada com a tuberculose e classificada no grupo das tuberculides.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hoje muitos autores a consideram como uma variante da ros\u00e1cea granulomatosa, opini\u00e3o que n\u00e3o \u00e9 consensual. Quem quiser reler o tema segue um link de revis\u00e3o &#8211;&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559065\/\">Lupus Miliaris Disseminatus Faciei<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Voltando ao artigo, os autores, utilizaram o tofacitinibe um inibidor de JAK com maior seletividade para JAK 1 e JAK 2, nos dois casos relatados, .&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A fundamenta\u00e7\u00e3o dos autores para usar o tofacitinibe foram relatos pr\u00e9vios. A l\u00f3gica sempre foi a rela\u00e7\u00e3o entre o uso do tofacitinibe e granuloma cut\u00e2neo, no caso a capacidade da medica\u00e7\u00e3o desmanchar o granuloma. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>H\u00e1 relatos que utilizam o TOFA no tratamento de outras doen\u00e7as granulomatosas. O ponto fr\u00e1gil \u00e9 que os autores n\u00e3o entraram em detalhes em rela\u00e7\u00e3o aos mecanismos envolvidos na forma\u00e7\u00e3o do granuloma nas distintas doen\u00e7as<\/li>\n\n\n\n<li>Um segundo argumento foi uma publica\u00e7\u00e3o que evidenciou melhorara do Lupus Miliaris Disseminatus Faciei com ruxolitinibe t\u00f3pico (ainda n\u00e3o dispon\u00edvel no Brasil).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Quando olho o artigo como um todo, lembro que s\u00e3o apenas dois relatos.<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>Destaco que se temos uma medica\u00e7\u00e3o capaz de desfazer granuloma, vamos precisar ficar de olho em doen\u00e7as infecciosas cr\u00f4nicas como a tuberculose.<\/p><\/blockquote><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Chamo a aten\u00e7\u00e3o que nos casos relatados, as repostas n\u00e3o foram homog\u00eaneas, desta forma, n\u00e3o podemos prever a resposta.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Entendo tamb\u00e9m que n\u00e3o podemos indicar como primeira escolha os inibidores de JAK, para as doen\u00e7as granulomatosas n\u00e3o infecciosas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vamos continuar de olho nas publica\u00e7\u00f5es e vamos anotar esta possibilidade para casos refrat\u00e1rios ao tratamento ou disseminados com contra-inidica\u00e7\u00e3o para o uso de corticoester\u00f3ides.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Certamente \u00e9 um alento sabermos que temos mais uma possibilidade para o tratamento das doen\u00e7as granulomatosas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Voc\u00ea tem experi\u00eancia com o uso de inibidores de JAK nas doen\u00e7as granulomatosas n\u00e3o infecciosas?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Com o intu\u00edto de aprendermos mais lembre de compartilhar o seu caso e de marcar o pele digital<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hoje vamos falar do uso de tofacitinibe e granuloma cut\u00e2neo, na nossa s\u00e9rie de artigos listada no post Inibidores de\u00a0JAK v\u00e3o mudar a dermatologia Trago a publica\u00e7\u00e3o intitulada&nbsp;Two cases of lupus miliaris disseminatus faciei successfully treated with oral tofacitinib.&nbsp; Neste artigo os autores relatam dois casos de lupus miliaris disseminatus faciei tratados com tofacitinibe A [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[26,24,25],"class_list":["post-744","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-imunologia","tag-granuloma-nao-infeccioso","tag-inibidores-de-jak","tag-tofacitinibe"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tofacitinibe e granuloma cut\u00e2neo - Pele Digital<\/title>\n<meta name=\"description\" content=\"Tofacitinibe e granuloma cut\u00e2neo. 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